Brief
Azelaic Acid (CAS No. 123-99-9) is a naturally occurring dicarboxylic acid derived from grains such as wheat, rye, and barley, and is also produced naturally by the skin’s microbiota. It has gained significant attention in dermatology and cosmetics for its anti-inflammatory, antibacterial, and skin-brightening properties. Azelaic acid is widely used in formulations for acne treatment, rosacea relief, and hyperpigmentation correction due to its ability to gently regulate skin cell turnover and melanin production.
What is Azelaic acid?
Azelaic Acid is a naturally occurring saturated nine-carbon dicarboxylic acid (chemical formula C9H16O4, molecular weight 188.22 g/mol). It appears as a white crystalline powder that is slightly soluble in water but dissolves well in alcohols and glycols. In dermatology and cosmetic science, azelaic acid is valued for its multifaceted biological activity, including antibacterial, anti-inflammatory, keratolytic, and melanin-inhibiting effects. It works by reducing the growth of acne-causing bacteria such as Propionibacterium acnes and by normalizing the process of keratinization within hair follicles to prevent clogged pores. Additionally, azelaic acid inhibits the enzyme tyrosinase, which is responsible for melanin synthesis, thereby helping to fade hyperpigmentation and even out skin tone. Its gentle yet effective mechanism of action makes it suitable for sensitive skin and a preferred ingredient in treatments for acne, rosacea, and melasma. With proven efficacy and safety, azelaic acid has become a key active ingredient in both cosmetic skincare products and pharmaceutical formulations used for improving skin clarity and texture.
What are the specifications?
▶ Azelaic acid powder
Chemical Name: Nonanedioic acid
CAS No.: 123-99-9
Molecular Formula: C9H16O4
Molecular Weight: 188.22 g/mol
Purity: ≥ 99% (HPLC)
Appearance: White to off-white crystalline powder
Solubility: Slightly soluble in water; soluble in ethanol, propylene glycol
What does Azelaic acid do?
▶ Key Benefits and Functions:
- Fights acne and blemishes – Inhibits bacterial growth and reduces inflammation, helping prevent breakouts.
- Brightens skin tone – Blocks tyrosinase, an enzyme responsible for melanin production, reducing hyperpigmentation and dark spots.
- Unclogs pores – Normalizes keratinization to prevent buildup of dead skin cells.
- Soothes redness and rosacea – Calms irritation and redness by reducing inflammatory responses.
- Safe for sensitive skin – Non-photosensitizing and suitable for long-term use compared to stronger agents like hydroquinone or benzoyl peroxide.
▶ Applications:
- Cosmetic creams, gels, and serums (concentrations 5–15%)
- Pharmaceutical-grade treatments for acne and rosacea (15–20%)
- Whitening and brightening formulations in skincare
- Combination formulations with niacinamide, retinoids, or salicylic acid
Conclusion
Azelaic Acid is a versatile, dermatologist-recommended ingredient offering anti-acne, brightening, and anti-inflammatory benefits. With its natural origin and gentle efficacy, it’s an ideal active compound for formulations targeting uneven skin tone, blemishes, and redness. Whether in pharmaceutical creams or cosmetic serums, azelaic acid stands as a scientifically validated, safe, and effective solution for achieving smoother, clearer, and healthier skin.
What packaging do we use?
Purchase Link：
https://www.corepurebio.com/product/azelaic-acid/
Contact us
E-mail: tina@corepurebio.com
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