Brief
7,8-Dihydroxyflavone (CAS No. 38183-03-8) is a naturally occurring flavone derivative known for its potent neuroprotective and cognitive-enhancing effects. It acts as a selective TrkB (tropomyosin receptor kinase B) receptor agonist, mimicking the activity of brain-derived neurotrophic factor (BDNF) — a key protein involved in neuron growth, survival, and plasticity. Because of this unique mechanism, 7,8-dihydroxyflavone has become a focus of interest in neuroscience research, cognitive health supplements, and anti-aging formulations.
What is 7,8-Dihydroxyflavone?
7,8-Dihydroxyflavone (often abbreviated as 7,8-DHF) is a small-molecule flavone found in trace amounts in some plants, though most commercial products are synthetically produced to achieve high purity. Unlike other flavonoids that primarily function as antioxidants, 7,8-DHF can directly activate the TrkB receptor, triggering downstream signaling pathways (PI3K/Akt and MAPK/ERK) that support neuronal survival and synaptic function.
Its ability to cross the blood-brain barrier makes it a valuable candidate for neurological and cognitive support.
What are the specifications?
▶ 7,8-Dihydroxyflavone powder
Chemical Name: 7,8-Dihydroxyflavone
CAS Number: 38183-03-8
Molecular Formula: C15H10O5
Molecular Weight: 270.24 g/mol
Purity: ≥ 98% (HPLC)
Appearance: Light yellow crystalline powder
Solubility: Poorly soluble in water; soluble in DMSO, ethanol, and methanol
What does 7,8-Dihydroxyflavone’s function?
Key Biological Functions:
- Neuroprotection – activates TrkB signaling, promoting neuronal growth and preventing cell death
- Cognitive enhancement – supports learning, memory, and synaptic plasticity
- Mood regulation – may help balance neurotransmitter systems linked to anxiety and depression
- Anti-aging support – protects brain cells from oxidative and age-related decline
- Antioxidant activity – scavenges free radicals and reduces inflammation in neural tissue
Applications:
- Nootropic and cognitive supplements targeting brain performance and neuroprotection
- Pharmaceutical research into neurodegenerative diseases such as Alzheimer’s and Parkinson’s
- Functional nutrition formulations supporting mental clarity and brain health
Conclusion
7,8-Dihydroxyflavone is an innovative neurotrophic flavonoid that stands out for its ability to mimic BDNF and activate TrkB receptors — a mechanism rarely found in natural compounds. With strong neuroprotective and cognitive-enhancing potential, it is becoming a key ingredient in advanced brain health and anti-aging formulations. Continued research may further establish its role in maintaining long-term cognitive vitality and mental performance.
What packaging do we use?
Purchase Link：https://www.corepurebio.com/product/dihydroxyflavone/
Contact us
E-mail: tina@corepurebio.com
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